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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are often characterized by their focus on practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use routinely available equipment.
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A pragmatic study that involves various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for practical trials to be valid and helps to reduce the chance of bias in the results. However too much heterogeneity could cause issues with the design of the trial.
Pragmatic Play, a major player on the live casino market, provides an array of traditional table games, including Blackjack and Roulette. The live studios of the company in Romania and Malta offer a real-life gambling experience for customers, as well as a wide range of virtual betting options. The company has also created numerous interactive game shows that make gambling online enjoyable. Some of these shows are broadcast live and others include famous people from the field.
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Legality
Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. Its software is designed to work with mobile devices and is compatible with different languages. It has earned itself the status of one of the top gaming platforms for casinos despite its relatively young age. The latest releases include Wolves which is a five-reel video slot with a healthful RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.
The goal of pragmatic trials is to replicate real-life situations and achieve maximum credibility externally. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They also provide a useful method to determine the cause-effect relationship between an intervention and its results. They should, however, not be used to replace explanation studies.
The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis as well as pragmatic trials that inform policy and practice decisions. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the elements of a pragmatic study that include the recruitment process, the design and implementation of the intervention, as well as monitoring.
There is a positive trend in the number of pragmatic trials that have been published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) produced 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority of studies were conducted in primary-care settings.